Topology independent comparison of RNA 3D structures using the CLICK algorithm
نویسندگان
چکیده
منابع مشابه
Topology independent comparison of RNA 3D structures using the CLICK algorithm
RNA molecules are attractive therapeutic targets because non-coding RNA molecules have increasingly been found to play key regulatory roles in the cell. Comparing and classifying RNA 3D structures yields unique insights into RNA evolution and function. With the rapid increase in the number of atomic-resolution RNA structures, it is crucial to have effective tools to classify RNA structures and ...
متن کاملCLICK—topology-independent comparison of biomolecular 3D structures
Our server, CLICK: http://mspc.bii.a-star.edu.sg/click, is capable of superimposing the 3D structures of any pair of biomolecules (proteins, DNA, RNA, etc.). The server makes use of the Cartesian coordinates of the molecules with the option of using other structural features such as secondary structure, solvent accessible surface area and residue depth to guide the alignment. CLICK first looks ...
متن کاملBiological insights from topology independent comparison of protein 3D structures
Comparing and classifying the three-dimensional (3D) structures of proteins is of crucial importance to molecular biology, from helping to determine the function of a protein to determining its evolutionary relationships. Traditionally, 3D structures are classified into groups of families that closely resemble the grouping according to their primary sequence. However, significant structural sim...
متن کاملIsogeometric Topology Optimization of Continuum Structures using an Evolutionary Algorithm
Topology optimization has been an interesting area of research in recent years. The main focus of this paper is to use an evolutionary swarm intelligence algorithm to perform Isogeometric Topology optimization of continuum structures. A two-dimensional plate is analyzed statically and the nodal displacements are calculated. The nodal displacements using Isogeometric analysis are found to be ...
متن کاملTopology of RNA-RNA Interaction Structures
The topological filtration of interacting RNA complexes is studied, and the role is analyzed of certain diagrams called irreducible shadows, which form suitable building blocks for more general structures. We prove that, for two interacting RNAs, called interaction structures, there exist for fixed genus only finitely many irreducible shadows. This implies that, for fixed genus, there are only ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2016
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkw819